Add time:08/08/2019         Source:sciencedirect.com

The present work reports the synthesis and evaluation of the antitumour and immunomodulatory properties of new phthalimides derivatives designed to explore molecular hybridization and bioisosterism approaches between thalidomide, thiosemicarbazone, thiazolidinone and thiazole series. Twenty-seven new molecules were assessed for their immunosuppressive effect toward TNFα, IFNγ, IL-2 and IL-6 production and antiproliferative activity. The best activity profile was observed for the (6a–f) series, which presents phthalyl and thiazolidinone groups.

We also recommend Trading Suppliers and Manufacturers of N-(4-AMINO-2-CHLOROPHENYL)PHTHALIMIDE (cas 19348-53-9). Pls Click Website Link as below: cas 19348-53-9 suppliers