Add time:08/08/2019         Source:sciencedirect.com

Nuclear magnetic resonance spectra of 2′-deoxyadenosine (dA) were measured at several solute concentrations in binary solvent mixture (D2Odimethyl sulphoxide) varying in composition from 0% to 100% by vol. D2O. One type of upfield shift of the C2 and C8 protons of the base moiety was found to be dA concentration dependent. In the range of dA concentrations studied, this upfield shift, due to base stacking interactions, decreases with decreasing D2O proportion until it vanishes at about 40–50% of D2O; this is near the concentration found to induce RNA denaturation. On the other hand, the other type of upfield shift, in water concentration decreasing below 40%, was found to be dA concentration independent and is interpreted, with corroboration from ultra-violet spectral measurements, as due to the hydration of dA.

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