Add time:08/05/2019         Source:sciencedirect.com

New metabolites of mesterolone, methenolone and stenbolone bearing a C18 hydroxyl group were isolated from the steroid glucuronide fraction of urine specimens collected after administration of single 50 mg doses of these steroids to human subjects. Mesterolone gave rise to four metabolites which were identified by gas chromatography/mass spectrometry as 18-hydroxy-1α-methyl-5α-androstan-3,17-dione 1, 3α,18-dihydroxy-1α- methyl-5α-androstan-17-one 2, 3β,18-dihydroxy-1α-methyl-5α-androstan-17-one 3 and 3α,6ξ,18-trihydroxy-1α-methyl-5α-androstan-17-one. 4. These data suggest that mesterolone itself was not hydroxylated at C18, but rather 1α-methyl-5α-androstan-3,17-dione, an intermediate metabolite which results from oxidation of mesterolone 17-hydroxyl group. In addition to hydroxylation at C18, reduction of the 3-keto grou[ and further hydroxylation at C6 were other reactions that led to the formation of these metabolites. It is of interest to note that in the case of both methenolone and stenbolone, only one 18-hydroxylated urinary metabolite namely 18-hydroxy-1-methyl-5α-androst-1-ene-3,17-dione 5 and 18-hydroxy-1- methyl-5α-androst-1-ene-3,17-dione 6 were both detected in post-administration urine specimens. These data indicate that the presence of a methyl group at the C1 or C2 positions in the steroids studied is a structural feature that seems to favor interaction of hepatic 18-hydroxylases with these steroids. These data provide further evidence that 18-hydroxylation of endogenous steroids can also occur in extra-adrenal sites in man.

We also recommend Trading Suppliers and Manufacturers of stenbolone acetate (cas 1242-56-4). Pls Click Website Link as below: cas 1242-56-4 suppliers