Add time:07/11/2019         Source:sciencedirect.com

A ‘one-flask’ synthesis of guanidines was developed by reacting isocyanates and isothiocyanates with sodium bis(trimethylsilyl)amide followed by addition of primary or secondary amines with a catalytic amount of AlCl3. The desired guanidines were obtained in good yields and the reaction was applicable to aliphatic and aromatic substrates. A plausible mechanism was proposed through the generation of cyanamide anion from isocyanates or isothiocyanates with sodium bis(trimethylsilyl)amide. Addition of amines and catalytic amount of AlCl3 smoothly converted the cyanamides to the desired guanidines.

We also recommend Trading Suppliers and Manufacturers of 3-BENZYLOXYPHENYL ISOTHIOCYANATE (cas 206559-36-6). Pls Click Website Link as below: cas 206559-36-6 suppliers