Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures-Science-Chemical Encyclopedia-lookchem

Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures
Add time:08/04/2019 Source:sciencedirect.com

BackgroundFalcipain 2 (FP-2) is the hemoglobin-degrading cysteine protease of Plasmodium falciparum most extensively targeted to develop novel antimalarials. However, no commercial antimalarial drugs based on FP-2 inhibition are available yet due to the low selectivity of most FP-2 inhibitors against the human cysteine proteases.

We also recommend Trading Suppliers and Manufacturers of 1-(9H-Fluoren-9-yl)-2,2-dimethyl-propan-1-one (cas 134886-88-7). Pls Click Website Link as below: cas 134886-88-7 suppliers

Prev:Site-directed mutation to improve the enzymatic activity of 5-carboxy-2-pentenoyl-CoA reductase for enhancing adipic acid biosynthesis
Next: Synthesis of some metallophthalocyanines bearing 9-phenyl-9H-fluoren-9-yl) oxy functional groups and investigation of their photophysical properties)

Click to view details

Encyclopedia