Add time:08/06/2019 Source:sciencedirect.com
An efficient and regioselective synthesis of functionalized benzenes via the cascade reactions of 1,2-allenic ketones with 4-sulfonyl crotonates under mild reaction conditions has been established. Mechanistically, the formation of the title compounds involves a cascade procedure consisting of an intermolecular regioselective Michael addition followed by an intramolecular condensation and aromatization. Compared with those of α,β-unsaturated aldehydes/ketones, the reactions of 1,2-allenic ketones with 4-sulfonyl crotonates demonstrated contrary regio-selectivity and distinct reaction conditions. Moreover, the functionalized benzene products obtained herein were found to be ready intermediates for the synthesis of fluorenone and anthracenone derivatives.
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