Add time:08/06/2019         Source:sciencedirect.com

An efficient and straightforward nucleophilic substitution reaction between 2-(trifluoromethyl)-2-hydroxy-2H-chromenes and various silyl enol ethers promoted by Lewis acid has been studied. A series of novel 4-functionalized-2-trifluoromethyl-3-ethoxycarbonyl-4H-chromenes were prepared in good yields under mild conditions.

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