Add time:08/05/2019         Source:sciencedirect.com

Optical resolution by micellar electrokinetic chromatography with N-dodecanoyl-l-serine (DSer) was investigated. Similarly to the use of sodium N-dodecanoyl-l-valinate or sodium N-dodecanoyl-l-glutamate, addition of sodium dodecyl sulfate (SDS), urea and organic modifiers such as methanol and 2-propanol (IPA) to DSer micellar solutions could give improved peak shapes and enhance the enantioselectivity. With a DSer-SDS-urea-methanol solution, six phenylthiohydantoin (PTH)dl-amino acids were separated and each enantiomeric pair was optically resolved. By using a DSer-SDS-urea-IPA solution, the same PTH-dl-amino acids were partially resolved, while PTH-dl-Thr was resolved only in this system. N-Dodecanoyl-l-aspartic acid and sodium N-tetradecanoyl-l-glutamate were also investigated, but satisfactory results were not obtained.

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