Add time:08/06/2019         Source:sciencedirect.com

A new fluorescence probe based on phenothiazine-coumarin platform was rationally designed and developed for the detection of hypochlorite (cas 14380-61-1) in a ratiometric manner in aqueous solution and living cells. The probe possessed a large pseudo Stokes shift (209 nm) and lager gap between two emissions (462/629 nm), which should avail to perform more accurate detection. The probe could respond to hypochlorite with selectivity, sensitivity and celerity. Moreover, the probe was successfully used for imaging endogenous hypochlorite in mitochondria of RAW264.7 macrophage cells with high sensitivity.

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