Add time:07/11/2019         Source:sciencedirect.com

Identification and synthesis of novel 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as glucokinase activators are described. Removal of an aniline structure of the prototype lead (2a) and incorporation of an alkoxy or phenoxy substituent led to the identification of 3-Isopropoxy-5-[4-(methylsulfonyl)phenoxy]-N-(4-methyl-1,3-thiazol-2-yl)benzamide (27e) as a novel, potent, and orally bioavailable GK activator. Rat oral glucose tolerance test indicated that 27e exhibited a glucose-lowering effect after 10 mg/kg oral administration.

We also recommend Trading Suppliers and Manufacturers of methyl 3-iodo-4-phenoxybenzoate (cas 100725-29-9). Pls Click Website Link as below: cas 100725-29-9 suppliers