Add time:07/11/2019         Source:sciencedirect.com

A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22–76.30%, 2.85–76.03% and 10.98–82.05% respectively at 10−5 concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.

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