Add time:08/06/2019         Source:sciencedirect.com

Soil-borne plant pathogens such as nematodes, fungi and some bacteria not only affect the plant cultures but also economy and environmental implications. As a result of these pathogens attacks, the yield and quality of crops is affected. Therefore, synthesis of new compounds to control these pathogens is very important and need of time. Chromenes are considered important group of heterocyclic compounds and exhibited significant biological activities. 2-amino-3-cyano chromenes are considered important medicinal scaffolds among the chromenes. We describe three component microwave assisted synthesis of 2-amino-3-cyano chromenes. The versatility of the reaction was examined by varying the aldehydes in the reaction mixture which lead to the synthesis of series of 2-amino-3-cyanochromenes (1–9). The structural elucidations of the compounds were studied by 1H NMR, 13C NMR, HRMS and FTIR spectrometer and results were well correlated. The synthesized compounds were evaluated for their anti-bacterial, anti-fungal and nematicidal activities. Among the synthesized compounds, compound 6 showed good anti-bacterial activity while compound 9 exhibited high anti-fungal activity. In case of nematicidal activity, compound 8 indicated high activity as compare with other compounds followed by compound 9. Results indicate that these synthesized compounds could be used as effective control for soil-borne plant pathogens such as nematodes, fungi and bacteria and can help to improve the plant production.

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