Add time:08/11/2019         Source:sciencedirect.com

1. leucomyosuppressin (cas 106884-19-9) (LMS) inhibited neurally evoked contractions of the hindgut of the cockroach Leucophaea maderae. The threshold for this inhibition of LMS was in the range of 1 × 10−10 M.2. LMS caused a sharp reduction in both l-glutamate and proctolin induced contractions. Dose-response profiles of the effect of LMS (held constant at 10−8M) on variable amounts of proctolin showed an inhibitory effect at 10−9 M proctolin and below, but at 5 × 10−9 M proctolin and above, LMS caused no inhibition.3. Potassium (158 mM) depolarized hindguts treated with LMS (10−8 M) showed a marked reduction (76% ± 2.1) in the proctolin (10−8 M) response.4. When calcium depleted preparations were returned to normal calcium levels (2 mM) in the presence of proctolin (10 −8 M) a contraction occurred that was 45% ± 4 of the maximum in normal saline solution. However, LMS (10−8 M) reduced this response to only 28% ± 2 of the maximum.5. Proctolin (10−8 M) induced contractions in the presence of the manganous ions (2mM) fell to 63% ± 4 of the maximum but on the addition of LMS (10−8M), such responses fell to only 16% ± 5 of the maximum.6. These results offer evidence for a non-synaptic site of action for LMS and a perturbation of key calcium dependent events in the excitation-contraction coupling sequence of visceral muscle by this peptide.

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