Add time:08/06/2019 Source:sciencedirect.com
A novel chemiluminscence (CL) flow-through sensor for pipemidic acid is described. It was based on the sensitizing effect of pipemidic acid on the CL oxidation of sulfite by SODIUM BISMUTHATE (cas 12232-99-4) in H2SO4 media. The solid-phase sodium bismuthate was mechanicially immobilized on the sponge rubber inside of the CL flow cell as CL oxidant. The calibration graph is linear in the range 0.1–10 μg/ml with a detection limit of 6.2×10−8 g/ml (3σ). A complete analysis could be performed in 1 min with a relative standard deviation (R.S.D.) of 2.5% for 2 μg/ml pipemidic acid (n=8). This method has been successfully applied to determine pipemidic acid in pharmaceutical preparation.
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