Add time:08/06/2019         Source:sciencedirect.com

Subfractionation of rat liver microsomes by the use of rate-zonal centrifugation has been carried out using both normal and induced rats. Phenobarbital and methyl cholanthrene were found to have very distinctive effects on the distribution of cytochrome P-450 within the microsomal vesicles. The altered distribution observed with methyl cholanthrene is inhibited by thioacetamide and ethionine. These results suggest that the P-450 produced after treatment with methyl cholanthrene is preferentially formed in, or bound to, a vesicle distinct from that which contains the P-450 in the normal or phenobarbital-induced animal.

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