Add time:08/09/2019         Source:sciencedirect.com

A series of novel β-hydroxy-β-bis(trifluoromethyl)-imines (2a–j) and di(β-hydroxy-β-bis(trifluoromethyl))-diimines (3a–f) were prepared in moderate to good yields via a simple two-step approach: first, β-hydroxy-β-bis(trifluoromethyl)-ketones (1a–c) were obtained by a catalyst-free aldol reaction between liquid hexafluoroacetone sesquihydrate and ketones (acetone, acetophenone, and pinacolone, respectively); then, condensation of the latter fluorinated β-ketols 1a–c with primary amines or diamines was achieved in the presence of Lewis (montmorillonite, InBr3, La(OTf)3) or Brönsted (PTSA) acid catalysts. The molecular structures of mono- and di-β-hydroxy-β-bis(trifluoromethyl)-(di)imines 2e,h and 3a,f were determined and found to exhibit strong intramolecular (R)N⋯H–O hydrogen bonding.

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