Add time:08/06/2019         Source:sciencedirect.com

The synthesis of 2H- and 3H-pyrazolo[4′,3′:3,4]pyrido[1,2-a]benzimidazole derivatives from 3-alkynyl- or 5-alkynylpyrazole-4-carbaldehydes and benzene-1,2-diamines was carried out using copper-free tandem cyclisation. When 2,3-diaminopyridine was used as the diamine component in this type of tandem cyclisation, 3H-pyrazolo[4,3-c]imidazo[1,2-a:5,4-b′]dipyridine derivatives were obtained. Copper catalysis and microwave activation were required for the reaction of 5-alkynylpyrazole-4-carbaldehydes and 1,8-naphthalenediamine, affording the corresponding 13,13a-dihydro-3H-pyrazolo[4′,3′:3,4]pyrido[1,2-a]perimidines. The structure assignments were based on data from 1H, 13C and 15N spectroscopy and single-crystal X-ray diffraction analyses. The optical properties of the obtained new heterocyclic derivatives were studied by UV–vis and fluorescence spectroscopy.

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