Add time:08/08/2019         Source:sciencedirect.com

The structural requirements of retro-thiorphan, N-[1R,S-benzyl-2-mercaptoethyl]malonamic acid 2, analogs for the inhibition of endothelin converting enzyme (ECE) were investigated. Although based on a single amino acid residue, N-[1R-(1H-indol-3-ylmethyl)-2-mercaptoethyl]-2-phenylacetamide 28 was found to be two times more potent than the widely utilized reference inhibitor phosphoramidon.

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