HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues-Science-Chemical Encyclopedia-lookchem

HIF-1α inhibitors: Synthesis and biological evaluation of novel Moracin O (cas 123702-97-6) and P analogues
Add time:08/08/2019 Source:sciencedirect.com

The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold. Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1α protein accumulation and target gene expression under hypoxia.

We also recommend Trading Suppliers and Manufacturers of Moracin O (cas 123702-97-6). Pls Click Website Link as below: cas 123702-97-6 suppliers

Prev:Moracin derivatives from Morus Radix as dual BACE1 and cholinesterase inhibitors with antioxidant and anti-glycation capacities
Next: Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo)

Click to view details

Encyclopedia