Add time:08/07/2019         Source:sciencedirect.com

Differential scanning calorimetry (DSC) data, in conjunction with Fourier transform infrared (FTIR) spectroscopy and X-ray powder diffraction (XRPD), was used to discriminate various polymorphic forms of zanoterone. The solid-state degradation rate of form IV (hemihydrate A) was found to be greater than that of form III at 40°C/25% RH and 40°C/75% RH. At 40°C/75% RH, the rate of degradation was 4-fold higher for form IV vs form III. Mixtures of forms III and IV were observed following desolvation of the acetonitrile solvate at 40°C with humidity levels of 60 and 70% RH, while at 40°C and 20–40% RH pure form III was formed. At 60°C, a mixture of forms III and IV was observed at 70% RH but not at lower relative humidity. The concentration of each form of zanoterone in solution was measured as a function of time at room temperature in 3% sodium lauryl sulfate. Forms I, II, and V showed greater initial concentrations than form III, but the values decreased with time due to the precipitation of form VI (hemihydrate B). Therefore, concentrations measured for forms I, II, and V were not equilibrium solubilities for these forms. Forms IV and VI showed lower initial concentrations (than form III) which did not change significantly with time.

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