α-Trifluoromethyl-β-aryl enamines in the synthesis of trifluoromethylated heterocycles by the Fischer and the Pictet–Spengler reactions-Science-Chemical Encyclopedia-lookchem

α-Trifluoromethyl-β-aryl enamines in the synthesis of trifluoromethylated heterocycles by the Fischer and the Pictet–Spengler reactions
Add time:08/07/2019 Source:sciencedirect.com

α-Trifluoromethyl-β-aryl enamines were successfully used as synthetic equivalents of benzyltrifluoromethyl ketones in both the Fischer indole synthesis and the Pictet–Spengler reaction. Accordingly, 2-trifluoromethyl indoles and a variety of trifluoromethylated 4,5,6,7-terahydro-1H-pyridines including carbolines were synthesized in moderate to good yields.

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