Operationally convenient asymmetric synthesis of (S)- and (R)-3-amino-4,4,4-trifluorobutanoic acid-Science-Chemical Encyclopedia-lookchem

Operationally convenient asymmetric synthesis of (S)- and (R)-3-amino-4,4,4-trifluorobutanoic acid
Add time:07/12/2019 Source:sciencedirect.com

An asymmetric synthesis of (S)- and (R)-3-amino-4,4,4-trifluorobutanoic acid via DBU-catalyzed asymmetric 1,3-proton shift transfer reaction of (Z)-3-[(R)-1-phenylethylamino]-4,4,4-trifluoro-N-[(R)-1-phenylethyl]but-2-enamide has been developed. The intermediate Schiff base (S,R′)-9 was found to be relatively configurationally stable under the highly basic reaction conditions allowing preparation of the target amino acid in high chemical yield and enantioselectivity. This method was demonstrated to be practical for large (>25 g) scale synthesis of the target β-amino acid.

We also recommend Trading Suppliers and Manufacturers of 3-OXO-N-(3-(TRIFLUOROMETHYL)PHENYL)BUTANAMIDE (cas 785-74-0). Pls Click Website Link as below: cas 785-74-0 suppliers

Prev:High cytoplasmic Ca2+ levels reached during Ca2+-induced Ca2+ release in single smooth muscle cell as reported by a low affinity Ca2+ indicator Mag-Indo-1
Next: Syntheses of 2-(trifluoromethyl)-1,3-dicarbonyl compounds through direct trifluoromethylation with CF3I and their application to fluorinated pyrazoles syntheses)

Click to view details

Encyclopedia