Add time:07/13/2019         Source:sciencedirect.com

A variety of 2-amino-3-cyano-5-oxo-4-perfluoroalkyl-5,6,7,8-tetrahydro-4H-chromene derivatives were achieved via a one-pot, three-component reaction from easily available methyl 2-perfluoroalkynoate, malononitrile (or ethyl cyanoacetate), and diverse cyclic 1,3-diketones. Moderate to good yields (up to 93%) were obtained in the presence of catalytic methylamine. This process went through a tandem Michael addition–cyclization reaction and was mild and easily performed.

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