Add time:07/12/2019         Source:sciencedirect.com

A new strategy for nucleophilic addition to aldehydes with difluoromethyl organometallic reagents has been developed by functionalizing the difluoromethyl moiety with the phenylsulfonyl group (SO2Ph). This electron-withdrawing group influences both the thermodynamic stability and the nucleophilicity of difluoromethyl organometallic reagents, which plays an important role in the nucleophilic difluoromethylation of aldehydes.

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