Enantiomers of (2R∗,3R∗)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid as novel chiral resolving agents-Science-Chemical Encyclopedia-lookchem

Enantiomers of (2R∗,3R∗)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid as novel chiral resolving agents
Add time:08/08/2019 Source:sciencedirect.com

A series of (2R∗,3R∗)-1-methyl-5-oxo-2-aryltetrahydro-1H-pyrrolidine-3-carboxylic acids were prepared and their structures were proven with X-ray crystallography. Racemic acid 5 has been resolved into enantiomers (2S,3S)-5 and (2R,3R)-5 by the formation of diastereomeric salts with brucine 9 and strychnidine 10, respectively. The ability of these enantiomers to serve as chiral discriminating agents was demonstrated by the chromatographic separation of diastereomeric amides and esters. Also, some preliminary results on the enantioselective reduction of prochiral imines with sodium borohydride modified by (2R,3R)-5 were collected.

We also recommend Trading Suppliers and Manufacturers of METHYL 5-OXO-1-(2-PHENYLETHYL)PYRROLIDINE-3-CARBOXYLATE (cas 100718-54-5). Pls Click Website Link as below: cas 100718-54-5 suppliers

Prev:Determination of the absolute configuration of (+)- and (−)-N-CBZ-3-fluoropyrrolidine-3-methanol using vibrational circular dichroism and confirmation of stereochemistry by conversion to (R)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl)pyrrolidine-1-carboxylate
Next: α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles)

Encyclopedia