Add time:08/08/2019         Source:sciencedirect.com

A series of 1N-substituted derivatives of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) has been prepared as constrained analogs of γ-substituted glutamic acids and examined for their effects at recombinant metabotropic glutamate receptor (mGluR) subtypes in vitro. Appropriate substitution of the 1N position of 2R,4R-APDC resulted in the identification of a number of selective group II mGluR antagonists.

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