Add time:08/08/2019         Source:sciencedirect.com

Diol (R)-(+)-3 is prepared either from the hydroxyketone 2 by reduction with fermenting baker's yeast or by hydrolysis of the dioxolane (R)-(+)-1 which is available from dimethyl d-malate as starting material. (R)-(+)-3 could be converted stereoselectively into (R)-(+)-4. Reaction of (+)-4 with dodecylmagnesium bromide yielded the alcohol (S)-(−)-5 with >99% ee. Its acetylation gave (S)-(+)-6 and hydrogenolysis gave the primary alcohol (S)-(+)-7 which could be oxidized selectively to (S)-(+)-8 with NaIO4RuCl3. Alkaline hydroysis of (+)-8 yielded 3-hydroxyhexadecanoic acid (S)-(+)-9 which could be esterified to give the methyl ester (S)-(+)-10 with >99% ee. Starting with the dioxolane (S)-(−)-1, derived from dimethyl l-malate, the 3-hydroxyhexadecanoic acid (R)-(−)-9 and its methyl ester (R)-(−)-10 could be synthesized via the intermediates (S)-(−)-3, (S)-(−)-4, (R)-(+)-5, (R)-(−)-6, (R)-(−)-7 and (R)-(−)-8.

We also recommend Trading Suppliers and Manufacturers of 3-HYDROXYHEXADECANOIC ACID METHYL ESTER (cas 127593-22-0). Pls Click Website Link as below: cas 127593-22-0 suppliers