Add time:08/10/2019         Source:sciencedirect.com

2,3-Difluoro-4,4-dimethyl-2-buten-4-olide (1) and spirocyclic 2,3-difluoro-4,4-(pentane-1,5-diyl)-2-buten-4-olide (2) were modified by vinylic displacement of fluorine with some O- and C-nucleophiles. Sodium and lithium alkoxides, substituted phenoxides and protected glucose alkoxides reacted by 1,4-addition followed by the expulsion of fluoride ion to give 3-substituted derivatives (4–24). Softer Grignard reagents in the form of a copper (I) bromide-dimethyl sulfide complex reacted in the same way as O-nucleophiles to afford 3-alkyl- or 3-aryl derivatives (25–26). Harder organolithium reagents attacked the carbonyl group to give unstable hydroxy compounds that rearranged spontaneously to furan(2H)-3-ones (27–29) in a novel oxygen rearrangement reaction.

We also recommend Trading Suppliers and Manufacturers of 3-Buten-2-one, 1-(2-methyl-1,3-dioxolan-2-yl)- (cas 127600-04-8). Pls Click Website Link as below: cas 127600-04-8 suppliers