Add time:08/08/2019         Source:sciencedirect.com

Substituted imidazoles (substituents are Me, Et, i-Bu, n-Hexyl, (CH2)2S–Bu-n, Ph, Bn) react smoothly (room temperature, without catalyst and solvent) with cyanoacetylenes (3-phenyl-2-propynenitrile and 4-(1-butoxyethoxy)-4-methyl-2-pentynenitrile) and aromatic or heteroaromatic aldehydes (benzaldehyde, 4-CN-benzaldehyde, pyridine-3-aldehyde) to give 3-(2-imidazolyl)-3-aryl-2-acylpropanenitriles, a hitherto unknown family of functionalized imidazole derivatives, in up to 62% yield. This three-component manifold represents a novel C(2)-functionalization of the imidazole nucleus involving zwitterionic, carbene and enol ether intermediates. Unlike the analogous reaction with aliphatic aldehydes, which gives enol ethers, in this case the latter undergo the further rearrangement to 3-(2-imidazolyl)-3-aryl-2-acylpropanenitriles.

We also recommend Trading Suppliers and Manufacturers of 2-[CYANO(PHENYL)METHYL]BENZENECARBONITRILE (cas 127667-03-2). Pls Click Website Link as below: cas 127667-03-2 suppliers