Add time:07/12/2019 Source:sciencedirect.com
On the basis of the previous lead N-4-t-butylbenzyl 2-(3-fluoro-4-methylsulfonylaminophenyl) propanamide (3) as a potent TRPV1 antagonist, structure–activity relationships for the B (propanamide part) and C-region (4-t-butylbenzyl part) have been investigated for rTRPV1 in CHO cells. The B-region was modified with dimethyl, cyclopropyl and reverse amides and then the C-region was replaced with 4-substituted phenyl, aryl alkyl and diaryl alkyl derivatives. Among them, compound 50 showed high binding affinity with Ki = 21.5 nM, which was twofold more potent than 3 and compound 54 exhibited potent antagonism with Ki(ant) = 8.0 nM comparable to 3.
We also recommend Trading Suppliers and Manufacturers of 3-cyclohexyl-N-(2-ethyl-6-methylphenyl)propanamide (cas 551907-94-9). Pls Click Website Link as below: cas 551907-94-9 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View