Add time:08/08/2019 Source:sciencedirect.com
The following compounds with higher antiallergic activities were isolated from eau de cologne mint leaves: 5,6,4′-trihydroxy-7,8-dimethoxyflavone (6), 5,6,4′-trihydroxy-7,8,3′-trimethoxyflavone (7), 5,6-dihydroxy-7,3′,4′-trimethoxyflavone (8), 5,6-dihydroxy-7,8,3′,4′-tetramethoxyflavone (9), and 5,6-dihydroxy-7,8,4′-trimethoxyflavone (10).The IC50 values of compounds 6–10 against RBL-2H3 cells were 6.7, 2.4, 5.6, 3.0, and 6.1 μM. Compounds 7 and 9 (IC50 2.4 μM and 3.0 μM) had the highest antiallergic activities among the flavonoids previously reported. The amounts of 7, 9, and 10 isolated were fairly high, at 177.7 mg/kg, 278.0 mg/kg, and 179.7 mg/kg in the mint, respectively. LD5 value (index of toxicity) and LD5/IC50 ratio of 7 and 9 indicate that the safety is greater than that of luteolin, a typical antiallergic substance. The extract containing powerful antiallergic flavones, 6–10 with higher hydrophobicity could be selectively separated from the extract containing luteolin and other flavonoid glycosides by partition with dichloromethane and water. Therefore, compounds 7 and 9 in mint, and the dichloromethane extract would be the most potent and preventive resources against type I allergy.
We also recommend Trading Suppliers and Manufacturers of 3',4',7,8-Tetramethoxy-5,6-dihydroxyflavone (cas 13509-93-8). Pls Click Website Link as below: cas 13509-93-8 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View