Add time:08/13/2019         Source:sciencedirect.com

Multiple biophysical methods demonstrate that silver effectively metallates Pseudomonas aeruginosa apo-AZURIN (cas 12284-43-4) in solution. X-ray crystallography of the silver-modified protein reveals that silver binds to azurin at the traditional copper mediated active site with nearly identical geometry. Cyclic voltammetry indicates that the silver adduct is redox inert. Our results suggest that a potential mechanism for the microbial toxicity of silver is the deactivation of copper oxidoreductases by the effective binding and structural mimicry by silver without the corresponding function.

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