Add time:07/15/2019         Source:sciencedirect.com

The formation of 5,11-dihydroindolo[3,2-b]carbazole, a polyaromatic hydrocarbon responsiveness-receptor agonist as well as an anti-initiator and promoter of carcinogenesis, from ascorbigen under conditions of chemical synthesis and during incubation with gastric juice at physiological conditions, is demonstrated. Ascorbigen, rather than indole-3-carbinol, is the most important indole derivative for the enzyme-inducing effects of dietary cruciferous vegetables. The concentration of ascorbigen in these vegetables is at least five times (in molar ratio) higher than that of indole-3-carbinol.

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