Add time:08/10/2019         Source:sciencedirect.com

The specific control of adrenal androgen secretion is unclear. This study was undertaken to investigate the effects of peptides derived from the ACTH precursor molecule pro-opiomelanocortin (POMC) on cortisol and androgen production using isolated guinea-pig adrenal cells. ACTH 10−13−10−9M, stimulated steroid production in a dose dependent manner, reaching a maximum of 12, 10 and 7 times basal levels for cortisol, androstenedione (A4) and dehydroepiandrosterone (DHEA), respectively, measured by specific radioimmunoassays. β-Lipotropin (β-LPH), 10−10−10−8M, also stimulated steroid production, reaching 6, 5 and 5 times basal levels of cortisol, A4 and DHEA, respectively. The N-terminal 16K fragment, λ3- and β-MSH stimulated steroid production which reached statistical significance (P < 0.05) only in the case of cortisol. Joining peptide, α-, β- and γ-endorphin resulted in no significant change in steroid production. Met- and leu-enkephalin resulted in significant inhibition of DHEA production. POMC-derived peptides altered the steroid response to ACTH. β-LPH and 16K fragment significantly increased the cortisol and A4 responses to a low concentration of ACTH. β-LPH reduced the maximum cortisol and A4 responses to a high concentration of ACTH. This study suggests that β-LPH may have a role in modulation of adrenal steroidogenesis but yielded no evidence to support a role for POMC-derived peptides in preferential stimulation of adrenal androgen production in guinea-pig adrenal cells.

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