Add time:08/12/2019         Source:sciencedirect.com

Three milligrams of cortisol-21 -sulfate or cortisol free alcohol in oil suspension was administered intramuscularly to male rats on alternate days for 2–7 weeks. Open-field tests repeated at 2- or 3-day intervals revealed that both steroids had significant stimulatory effects on the animal's exploratory behaviors (ambulation and rearing), when the treatments were started soon after weaning (postnatal day 21–24). The same treatments to adult rats (46 days old), however, did not cause any change in the activity levels. It was also shown that cortisol sulfate, in contrast to free cortisol, was inert as a glucocorticoid; it had no catabolic, gluconeogenic, lympholytic, or ACTH-suppressive effects. The results suggest that cortisol sulfate, and probably free cortisol as well, affects behavior through its direct action on the central nervous system rather than via its effects on intermediary metabolism or negative feedback on pituitary ACTH release.

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