Add time:08/10/2019         Source:sciencedirect.com

methylmalonyl-coenzyme A (cas 1264-45-5) (CoA) mutase, methylmalonyl-CoA decarboxylase and NADP+-isocitrate dehydrogenase activity profiles were determined in Saccharopolyspora erythraea CA340, an erythromycin producer, grown in glucose or ammonium chloride. Results show that methylmalonyl-CoA mutase and isocitrate dehydrogenase activities were associated with growth, while methylmalonyl-CoA decarboxylase maximal activity was observed at stationary phase. Isocitrate dehydrogenase synthesis was stimulated by glucose and repressed by ammonium; glucose affected negatively the synthesis of methylmalonyl-CoA mutase, whereas methylmalonyl-CoA decarboxylase production was not affected by carbon or nitrogen sources. These results suggested that the negative effect of glucose or ammonium on erythromycin production could be due, in part, to lower pools of succinyl-CoA and methylmalonyl-CoA.

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