Add time:07/13/2019         Source:sciencedirect.com

The synthesis of poly(L-tyrosyl-e-N-L-glutamyl-L-lysyl-L-alanylglycyl)glycine methyl ester (I) is described. This material neither crossreacts with antibodies to poly(L-tyrosyl-L-glutamyl-L-alanylglycyl)glycine-1-14C ethyl ester nor inhibits the precipitin reaction between these antibodies and the homologous antigen. It was concluded that this lack of crossreaction and inhibitory properties of I is due to the antibodies to poly(L-tyrosyl-L-glutamyl-L-alanylgly-cyl)glycine-1-14C ethyl ester being highly dependent on the conformation of their homologous antigen.

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