Add time:08/10/2019         Source:sciencedirect.com

The solution chemistry of Ferric fructose (cas 12286-76-9) has been examined at various hydroxide-to-iron ratios using several physical techniques. The reactivity of ferric fructose complexes with transferrin, the serum iron binding protein, has provided a quantitative measure of polymeric fractions and insight into the rate and mode of breakdown of the polymers. A hydroxy-iron polymer is formed maximally (90%) in the neutral pH region corresponding to 3 OH/Fe, while mononuclear ferric fructose complexes predominate both in acidic (probably as FeFru(-H+)2+, and basic (probably as FeFru(-4H+)− solutions. The chemistry is similar to that of the ferric gluconate system, except that the carboxylate group of gluconate makes it more effective at breaking down the hydrolytic iron polymer. Both ligands form octahedral mononuclear complexes, and gluconate exhibits higher ligand field strength than fructose. The hydrolytic ferric fructose polymer shows the same spectrum as the ferric nitrate and ferric citrate polymers but is much smaller (mw<15,000) and more reactive. Autoreduction occurs in the ferric fructose system, and the rate is a complex function of the composition, but it is not rapid enough to account for the rate of depolymerization. Implications of these findings for the mechanism by which sugars facilitate the absorption of dietary iron are discussed.

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