Add time:08/09/2019         Source:sciencedirect.com

Publisher SummaryHeterosteroids have recently received much attention. The altered chemical and physical properties are envisaged to lead to the discovery of new substances having the potential of providing some useful drugs. Heterosteroids are divided into nucleo- and extranucleo-categories. The former contain heteroatoms in the nucleus, whereas in the latter, heteroatoms form part of a fused or spiro ring system, an attached group, or a side chain. The facets of heterosteroids discussed in this chapter pertain to adrenocorticoids, anti-mineralocorticoids, anabolics, androgen antagonists and biosynthesis inhibitors, oestrogenic, anti-oestrogenic, progestational, anti-progestational, anti-fertility, catatoxic, cardiac, anti-lipemic, central nervous system acting, neuromuscular blocking, local anaesthetic, diagnostic, antimicrobial, anti-neoplastic, and miscellaneous agents. Medicinal chemists have ventured to modify the corticosteroid structures in different ways and many highly successful drugs have resulted. The chapter focuses on hetero modifications and some closely related aspects. Certain hetero analogues of the mineralocorticoid deoxycorticosterone have been prepared and examined. Some of the synthetic compounds are adrenal inhibitors and anticatabolics.

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