Add time:08/09/2019         Source:sciencedirect.com

A highly efficient and practical protocol has been developed for the synthesis of 5-(hetero)arylated thiazole derivatives via an N-heterocyclic carbene palladium (Pd-NHC) complex catalyzed direct C-H arylation reaction. Utilization of this methodology, the arylation of substituted thiazoles with (hetero)aryl bromides efficiently proceeded at low catalyst loading (0.1–0.05 mol%) and under aerobic conditions. A variety of (hetero)aryl bromides, even some strongly deactivated or highly congested (hetero)aryl bromides, with a broad range of functional groups were compatible under the optimal reaction conditions. In all cases, the target products were afforded in moderate to quantitative yields.

We also recommend Trading Suppliers and Manufacturers of 4-(CHLOROMETHYL)-2-(TRIFLUOROMETHYL)THIAZOLE (cas 135207-07-7). Pls Click Website Link as below: cas 135207-07-7 suppliers