Add time:08/09/2019         Source:sciencedirect.com

Full details are given for the syntheses of the protease inhibitors, poststatin and eurystatin by the acyl cyanophosphorane coupling procedure used for the formation of α-keto amides. We have also extended this methodology to the syntheses of the related α-hydroxy amide natural products, phebestin, probestin and bestatin. The key step in the latter synthetic sequences involved diastereomeric selectivity in the reduction of the α-keto precursor to the corresponding α-hydroxy amide by the use of zinc borohydride.

We also recommend Trading Suppliers and Manufacturers of poststatin (cas 135219-43-1). Pls Click Website Link as below: cas 135219-43-1 suppliers