A convergent synthesis of poststatin: Application of the acyl cyanophosphorane coupling procedure in the formation of a peptidic α-keto amide-Science-Chemical Encyclopedia-lookchem

A convergent synthesis of poststatin (cas 135219-43-1): Application of the acyl cyanophosphorane coupling procedure in the formation of a peptidic α-keto amide
Add time:08/11/2019 Source:sciencedirect.com

A convergent synthesis of the pentapeptide poststatin has been developed. The key step involves oxidative cleavage of an acyl cyanophosphorane. The resulting α,β-diketo nitrile is then coupled to the free amine of a C-terminal-dipeptidyl component to generate the protected natural product. Deprotection by hydrogenolysis furnishes poststatin.

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