Add time:08/10/2019         Source:sciencedirect.com

Single topical treatment with l-adrenaline bitartrate in eyes of albino rabbits gave a prompt concentration-related increase in pupil diameter, peak values occurring at 1–2 hr. Ocular tension decrease commenced 2–3 hr after treatment, at the same time that the mydriatic effect started to decline. The decrease was concentration-related over approximately the same range as the pupil effect. Where a second topical treatment with a submaximal (0·5%) concentration of l-adrenaline bitartrate, equal to the first, was applied 3 or 4 hr later, a secondary delay in ocular hypotensive effect occurred and the tension returned to values not significantly different from controls for at least 1 hr. A second peak mydriasis occurred after the second treatment, equal in extent to the first. Onset of hypotension again coincided with offset of mydriasis. 0·25% l-Adrenaline bitartrate applied 3 hr after 0·5% caused a shorter secondary delay in tension fall and the mydriasis, although prolonged, did not give a further peak. 1% l-Adrenaline bitartrate applied 3 hr after 0·5% had similar effect on tension to the second treatment with 0·5%, but a significantly higher peak mydriasis occurred with 1%.No significant correlation was found between maximum observed pupil increases and tension decreases in a group of rabbits after a single treatment with a submaximal concentration of l-adrenaline bitartrate.0·5% l-Adrenaline bitartrate applied topically at 0 and 3 hr in the absence of tonometric procedures gave two equal peaks of mydriasis, but these were significantly lower than those found with similar treatment in the presence of tonometric procedures. Local anaesthetic applied for tonometry is implicated.

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