Add time:08/11/2019 Source:sciencedirect.com
This review chronicles the strategies and hurdles encountered in farnesyl transferase inhibitor drug discovery programs, with the major focus on substrate-based inhibitor design. Recently reported enzyme structure studies and their potential impact on drug design are also discussed. The anti-proliferative effect that FTIs exhibit in both genetically engineered and human tumor cell lines suggest that this type of drug may be efficacious in treating certain cancers.
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