Add time:07/14/2019         Source:sciencedirect.com

A series of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles 14a–e, 15a–e, 17a–c, and 18a–d have been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The 6-quinolinyl pyrazole analogue 14b inhibited ALK5 phosphorylation with IC50 value of 0.022 μM and showed 84% inhibition at 0.1 μM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct.

We also recommend Trading Suppliers and Manufacturers of N,N-dimethyl-2-(6-methylpyridin-2-yl)ethanethioamide (cas 31329-87-0). Pls Click Website Link as below: cas 31329-87-0 suppliers