Add time:08/11/2019         Source:sciencedirect.com

A series of 4-(amido-biarylether)-quinolines was prepared as potential LXR agonists. Appropriate substitution with amide groups provided high affinity LXR ligands, some with excellent potency and efficacy in functional assays of LXR activity. Novel amide 4g had a binding IC50 = 1.9 nM for LXRβ and EC50 = 34 nM (96% efficacy relative to T0901317) in an ABCA1 gene expression assay in mouse J774 cells, demonstrating that 4-(biarylether)-quinolines with appropriate amide substitution are potent LXR agonists

We also recommend Trading Suppliers and Manufacturers of 2-CHLORO-4-(MORPHOLIN-4-YLCARBONYL)QUINOLINE (cas 135323-95-4). Pls Click Website Link as below: cas 135323-95-4 suppliers