Add time:08/19/2019         Source:sciencedirect.com

The present work was aimed to synthesize leucite (cas 1302-34-7) based bioactive glass ceramic composite with required characteristics for dental applications. The leucite glass-ceramic was prepared using mechanochemical synthesis. The microstructural, thermal, mechanical and biological properties of the composite coatings and its material–cell interaction were studied. The flexural strength and coefficient of thermal expansion (CTE) of a commercial dentine was also studied comparatively. Results of FTIR indicated the formation of hydroxyapatite layer on the surface of the composite. In-vitro cell proliferation and cytotoxicity assay of MCL composite material demonstrated that it did not inhibit proliferation and cytotoxicity of SCC-25 at low concentration, caused moderate levels of apoptosis at higher concentrations and were also tolerated by human RBC as studied by hemolytic assay. Based on the toxicity and bioactivity observed in this work, it can be concluded that this product may be further processed for potential clinical applications.

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