A practical preparation of enantiomerically pure (R)- and (S)-2-bromohexadecanoic acids-Science-Chemical Encyclopedia-lookchem

A practical preparation of enantiomerically pure (R)- and (S)-2-BROMOHEXADECANOIC ACID (cas 18263-25-7)s
Add time:08/11/2019 Source:sciencedirect.com

The efficient preparation of enantiomerically pure (R)- and (S)-2-bromohexadecanoic acids with e.e.>95% through resolution with the use of a recoverable chiral auxiliary is described. The procedure involves three reactions: Steglich esterification, DIBAL reduction, and Sharpless oxidation. The assessment of the enantiomeric purity is based on NMR analysis by using (1R,2R)-(+)-diphenylethane-1,2-diamine as a chiral solvating agent.

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