Add time:08/13/2019         Source:sciencedirect.com

Cholesteryl oleyl carbonate (COC) was embedded in a cellulose nitrate membrane for the purpose of developing a drug delivery system with a thermal stimulus response. The thermophysical properties of COC were determined by thermal analysis and microscopic Fourier transform infrared spectroscopy with differential scanning calorimetry (Micro FTIR-DSC) to confirm its thermo-responsive property. The COC-embedded membrane was prepared by filtrating a certain amount of COC chloroform solution through the cellulose nitrate membrane using a vacuum filtration method. The thermo-responsive functions of COC-embedded membranes were investigated using a step-wise temperature change between 10°C and 25°C (below and above the gel-liquid crystal phase transition temperature of COC). The results indicate that the amount of COC adsorbed increased linearly with the increase of the COC concentration used. The permeation rate of salbutamol sulfate through the COC-embedded membrane was controlled by the amount of COC absorbed in the cellulose nitrate membrane, which could be confirmed by the observations of scanning electron microscopy (SEM) and contact angle measurements. The permeation of salbutamol sulfate through the membrane could be sensitively controlled by temperature changes. This implies the COC-embedded membrane may be used as a thermally on-off switching membrane for a stimuli-response controlled drug delivery system.

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