Add time:08/12/2019         Source:sciencedirect.com

A new Michael-initiated cyclopropanation reaction using α-bromochalcones as Michael acceptor was developed. Compared to previous works using arylidenemalonates as Michael acceptor, this novel protocol could improve the synthesis of trans-isomers of diethyl 2-benzoyl-3-phenyl-cyclopropane-1,1-dicarboxylates. More importantly, this method also provided the first access to the cis-isomers of these densely substituted cyclopropanes with the Michael-initiated ring closure (MIRC) strategy, albeit with a poor diastereoselectivity.

We also recommend Trading Suppliers and Manufacturers of DIETHYL 4-NITROPHENYL MALONATE (cas 10565-13-6). Pls Click Website Link as below: cas 10565-13-6 suppliers